Behavioural phenotyping of sodium-myo-inositol cotransporter heterozygous knockout mice with reduced brain inositol.

doi:10.1111/j.1601-183X.2006.00253.x

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Article

Behavioural phenotyping of sodium-myo-inositol cotransporter heterozygous knockout mice with reduced brain inositol.

Genes, brain, and behavior - 1 Apr 2007

Shaldubina A, Buccafusca R, Johanson R A, Agam G, Belmaker R H, Berry G T, Bersudsky Y

Abstract excerpt

Inositol plays a key role in dopamine, serotonin, noradrenaline and acetylcholine neurotransmission, and inositol treatment is reported to have beneficial effects in depression and anxiety. Therefore, a reduction in brain intracellular inositol levels could be a cause of some psychiatric disorders, such as depression or anxiety. To determine the behavioural consequences of inositol depletion, we studied the...

Topics

Analysis of Variance
Animals
Behavior, Animal
Female
Frontal Lobe
Heterozygote
Hippocampus
Inositol
Intracellular Fluid
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Models, Animal
Phenotype
Symporters

Source

Open in PubMed

Identifiers

PMID: 16848785
DOI: 10.1111/j.1601-183X.2006.00253.x

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