Article
Behavioural phenotyping of sodium-myo-inositol cotransporter heterozygous knockout mice with reduced brain inositol.
Genes, brain, and behavior - 1 Apr 2007
Shaldubina A, Buccafusca R, Johanson R A, Agam G, Belmaker R H, Berry G T, Bersudsky Y
Abstract excerpt
Inositol plays a key role in dopamine, serotonin, noradrenaline and acetylcholine neurotransmission, and inositol treatment is reported to have beneficial effects in depression and anxiety. Therefore, a reduction in brain intracellular inositol levels could be a cause of some psychiatric disorders, such as depression or anxiety. To determine the behavioural consequences of inositol depletion, we studied the...
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