Article
Genomic structure and novel variants of myo-inositol monophosphatase 2 (IMPA2).
Molecular psychiatry - 1 Mar 2000
Yoshikawa T, Padigaru M, Karkera J D, Sharma M, Berrettini W H, Esterling L E, Detera-Wadleigh S D
Abstract excerpt
Recently, we cloned the human myo-inositol monophosphatase 2 (IMPA2) cDNA and established its map location to chromosome 18p11.2, a region previously implicated in bipolar disorder. Because the myo-inositol monophosphatase enzyme has been shown to be inhibited by lithium, an effective therapeutic agent for bipolar disorder, IMPA2 is a plausible positional and functional candidate gene. To permit comprehensive...
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