Treatment of BXSB‐<i>Yaa</i> Mice with IL‐21R‐Fc Fusion Protein Minimally Attenuates Systemic Lupus Erythematosus

Abstract excerpt

Interleukin-21 (IL-21) is a pleiotropic cytokine whose function is only now being unraveled. Abundant evidence indicates that activated CD4 T cells are the primary, if not the only, source of IL-21. While it is clear that IL-21 is actively transcribed by naïve activated T cells, recent studies have shown that IL-21 potentially promotes a developmental shift of naïve T cells toward the Th2 phenotype. BXSB-Yaa mice...

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