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Article

Distinct modulations of human capsaicin receptor by protons and magnesium through different domains.

The Journal of biological chemistry - 9 Apr 2010

Wang Shu, Poon Kinning, Oswald Robert E, Chuang Huai-hu

Abstract excerpt

The capsaicin receptor (TRPV1) is a nonselective cation channel that integrates multiple painful stimuli, including capsaicin, protons, and heat. Protons facilitate the capsaicin- and heat-induced currents by decreasing thermal threshold or increasing agonist potency for TRPV1 activation (Tominaga, M., Caterina, M. J., Malmberg, A. B., Rosen, T. A., Gilbert, H., Skinner, K., Raumann, B. E., Basbaum, A. I., and...

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Source

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Identifiers

PMID: 20145248
DOI: 10.1074/jbc.M109.058727
PMCID: PMC2857033

Genes

TRPV1

Provenance

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