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Article

Molecular determinants of vanilloid sensitivity in TRPV1.

The Journal of biological chemistry - 7 May 2004

Gavva Narender R, Klionsky Lana, Qu Yusheng, Shi Licheng, Tamir Rami, Edenson Steve, Zhang T J, Viswanadhan Vellarkad N, Toth Attila, Pearce Larry V, Vanderah Todd W, Porreca Frank, Blumberg Peter M, Lile Jack, Sun Yax, Wild Ken, Louis Jean-Claude, Treanor James J S

Abstract excerpt

Vanilloid receptor 1 (TRPV1), a membrane-associated cation channel, is activated by the pungent vanilloid from chili peppers, capsaicin, and the ultra potent vanilloid from Euphorbia resinifera, resiniferatoxin (RTX), as well as by physical stimuli (heat and protons) and proposed endogenous ligands (anandamide, N-arachidonyldopamine, N-oleoyldopamine, and products of lipoxygenase). Only limited information is...

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Source

Identifiers

PMID: 14996838
DOI: 10.1074/jbc.M312577200

Genes

TRPV1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Molecular determinants of vanilloid sensitivity in TRPV1.PMID 14996838Read ↗

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Detailed Analysis of the Binding Mode of Vanilloids to Transient Receptor Potential Vanilloid Type I (TRPV1) by a Mutational and Computational Study.Semantic proximity Read ↗

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