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Article

Functional characterisation of the S512Y mutant vanilloid human TRPV1 receptor.

British journal of pharmacology - 1 Nov 2005

Sutton Kathy G, Garrett Elizabeth M, Rutter A Richard, Bonnert Timothy P, Jarolimek Wolfgang, Seabrook Guy R

Abstract excerpt

1 Mammalian transient receptor potential (TRP) channels include the nonselective cation channel TRPV1, which is activated by a range of stimuli including low pH, vanilloids and heat. Previously, selective mutagenesis experiments identified an intracellular residue (S512Y) critical to discriminating between pH and vanilloid (capsaicin) gating of the rat TRPV1 receptor. 2 In this study, switching the equivalent...

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Identifiers

PMID: 16100528
DOI: 10.1038/sj.bjp.0706356
PMCID: PMC1751200

Genes

TRPV1

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Functional characterisation of the S512Y mutant vanilloid human TRPV1 receptor.PMID 16100528Read ↗

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Acid potentiation of the capsaicin receptor determined by a key extracellular site.Semantic proximity Read ↗

A human TRPV1 genetic variant within the channel gating domain regulates pain sensitivity in rodentsSemantic proximity Read ↗

Functionally important amino acid residues in the transient receptor potential vanilloid 1 (TRPV1) ion channel--an overview of the current mutational data.Semantic proximity Read ↗

Protons stabilize the closed conformation of gain-of-function mutants of the TRPV1 channel.Semantic proximity Read ↗

Striving toward hyperthermia-free analgesia: lessons from loss-of-function mutations of human TRPV1.Semantic proximity Read ↗

Functional effects of nonsynonymous polymorphisms in the human TRPV1 gene.Semantic proximity Read ↗

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The molecular basis for species-specific activation of human TRPA1 protein by protons involves poorly conserved residues within transmembrane domains 5 and 6.Semantic proximity Read ↗

Tunable calcium current through TRPV1 receptor channels.Semantic proximity Read ↗

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