Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of species-specific determinants of the action of the antagonist capsazepine and the agonist PPAHV on TRPV1.

The Journal of biological chemistry - 23 Apr 2004

Phillips Elsa, Reeve Alison, Bevan Stuart, McIntyre Peter

Abstract excerpt

The vanilloid receptor 1 (VR1 or TRPV1) ion channel is activated by noxious heat, low pH and by a variety of vanilloid-related compounds. The antagonist, capsazepine is more effective at inhibiting the human TRPV1 response to pH 5.5 than the rat TRPV1 response to this stimulus. Mutation of rat TRPV1 at three positions in the S3 to S4 region, to the corresponding human amino acid residues I514M, V518L, and M547L...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Capsaicin
Share to Diterpenes
Share to Electrophysiology

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Guinea Pigs

Share to Inhibitory Concentration 50

Share to Phorbol Esters

Share to Receptors, Drug

Source

Identifiers

PMID: 14960593
DOI: 10.1074/jbc.M313328200

Genes

TRPV1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of species-specific determinants of the action of the antagonist capsazepine and the agonist PPAHV on TRPV1.PMID 14960593Read ↗

Molecular determinants of vanilloid sensitivity in TRPV1.Semantic proximity Read ↗

The molecular basis for species-specific activation of human TRPA1 protein by protons involves poorly conserved residues within transmembrane domains 5 and 6.Semantic proximity Read ↗

Functional characterisation of the S512Y mutant vanilloid human TRPV1 receptor.Semantic proximity Read ↗

A single TRPV1 amino acid controls species sensitivity to capsaicin.Semantic proximity Read ↗

Agonist-dependence of functional properties for common nonsynonymous variants of human transient receptor potential vanilloid 1.Semantic proximity Read ↗

Cloning and functional expression of a human orthologue of rat vanilloid receptor-1.Semantic proximity Read ↗

Acid potentiation of the capsaicin receptor determined by a key extracellular site.Semantic proximity Read ↗

Distinct modulations of human capsaicin receptor by protons and magnesium through different domains.Semantic proximity Read ↗

TRPV1.Semantic proximity Read ↗

Structural origins of species-specific differences in TRPV2 activation.Semantic proximity Read ↗

Molecular basis determining inhibition/activation of nociceptive receptor TRPA1 protein: a single amino acid dictates species-specific actions of the most potent mammalian TRPA1 antagonist.Semantic proximity Read ↗

Desensitization of capsaicin-activated currents in the vanilloid receptor TRPV1 is decreased by the cyclic AMP-dependent protein kinase pathway.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.