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Article

Identification of species-specific determinants of the action of the antagonist capsazepine and the agonist PPAHV on TRPV1.

The Journal of biological chemistry - 23 Apr 2004

Phillips Elsa, Reeve Alison, Bevan Stuart, McIntyre Peter

Abstract excerpt

The vanilloid receptor 1 (VR1 or TRPV1) ion channel is activated by noxious heat, low pH and by a variety of vanilloid-related compounds. The antagonist, capsazepine is more effective at inhibiting the human TRPV1 response to pH 5.5 than the rat TRPV1 response to this stimulus. Mutation of rat TR...

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Identifiers

PMID: 14960593
DOI: 10.1074/jbc.M313328200

Genes

TRPV1

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14960593-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Identification of species-specific determinants of the action of the antagonist capsazepine and the agonist PPAHV on TRPV1.PMID 14960593Read ↗

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Cloning and functional expression of a human orthologue of rat vanilloid receptor-1.Semantic proximity Read ↗

Acid potentiation of the capsaicin receptor determined by a key extracellular site.Semantic proximity Read ↗

Distinct modulations of human capsaicin receptor by protons and magnesium through different domains.Semantic proximity Read ↗

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Structural origins of species-specific differences in TRPV2 activation.Semantic proximity Read ↗

Molecular basis determining inhibition/activation of nociceptive receptor TRPA1 protein: a single amino acid dictates species-specific actions of the most potent mammalian TRPA1 antagonist.Semantic proximity Read ↗

Desensitization of capsaicin-activated currents in the vanilloid receptor TRPV1 is decreased by the cyclic AMP-dependent protein kinase pathway.Semantic proximity Read ↗

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