Article
Gene expression levels as endophenotypes in genome-wide association studies of Alzheimer disease.
Neurology - 9 Feb 2010
Zou F, Carrasquillo M M, Pankratz V S, Belbin O, Morgan K, Allen M, Wilcox S L, Ma L, Walker L P, Kouri N, Burgess J D, Younkin L H, Younkin Samuel G, Younkin C S, Bisceglio G D, Crook J E, Dickson D W, Petersen R C, Graff-Radford N, Younkin Steven G, Ertekin-Taner N
Abstract excerpt
BACKGROUND: Late-onset Alzheimer disease (LOAD) is a common disorder with a substantial genetic component. We postulate that many disease susceptibility variants act by altering gene expression levels. METHODS: We measured messenger RNA (mRNA) expression levels of 12 LOAD candidate genes in the c...
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