Article
An APOE-independent cis-eSNP on chromosome 19q13.32 influences tau levels and late-onset Alzheimer's disease risk.
Neurobiology of aging - 1 Jun 2018
Rao Shuquan, Ghani Mahdi, Guo Zhiyun, Deming Yuetiva, Wang Kesheng, Sims Rebecca, Mao Canquan, Yao Yao, Cruchaga Carlos, Stephan Dietrich A, Rogaeva Ekaterina
Abstract excerpt
Although multiple susceptibility loci for late-onset Alzheimer's disease (LOAD) have been identified, a large portion of the genetic risk for this disease remains unexplained. LOAD risk may be associated with single-nucleotide polymorphisms responsible for changes in gene expression (eSNPs). To detect eSNPs associated with LOAD, we integrated data from LOAD genome-wide association studies and expression...
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