Genetic control of human brain transcript expression in Alzheimer disease.

doi:10.1016/j.ajhg.2009.03.011

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Article

Genetic control of human brain transcript expression in Alzheimer disease.

American journal of human genetics - 1 Apr 2009

Webster Jennifer A, Gibbs J Raphael, Clarke Jennifer, Ray Monika, Zhang Weixiong, Holmans Peter, Rohrer Kristen, Zhao Alice, Marlowe Lauren, Kaleem Mona, McCorquodale Donald S, Cuello Cindy, Leung Doris, Bryden Leslie, Nath Priti, Zismann Victoria L, Joshipura Keta, Huentelman Matthew J, Hu-Lince Diane, Coon Keith D, Craig David W, Pearson John V, Heward Christopher B, Reiman Eric M, Stephan Dietrich, Hardy John, Myers Amanda J

Abstract excerpt

We recently surveyed the relationship between the human brain transcriptome and genome in a series of neuropathologically normal postmortem samples. We have now analyzed additional samples with a confirmed pathologic diagnosis of late-onset Alzheimer disease (LOAD; final n = 188 controls, 176 cases). Nine percent of the cortical transcripts that we analyzed had expression profiles correlated with their genotypes...

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Identifiers

PMID: 19361613
DOI: 10.1016/j.ajhg.2009.03.011
PMCID: PMC2667989

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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