Article
Replicative bypass of abasic site in Escherichia coli and human cells: similarities and differences.
PloS one - 1 Jan 2014
Weerasooriya Savithri, Jasti Vijay P, Basu Ashis K
Abstract excerpt
Abasic [apurinic/apyrimidinic (AP)] sites are the most common DNA damages, opposite which dAMP is frequently inserted ('A-rule') in Escherichia coli. Nucleotide insertion opposite the AP-site in eukaryotic cells depends on the assay system and the type of cells. Accordingly, a 'C-rule', 'A-rule', or the lack of specificity has been reported. DNA sequence context also modulates nucleotide insertion opposite...
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