Article
Transcriptional mutagenesis induced by uracil and 8-oxoguanine in Escherichia coli.
Molecular cell - 1 Oct 2003
Brégeon Damien, Doddridge Zara A, You Ho Jin, Weiss Bernard, Doetsch Paul W
Abstract excerpt
Cells exposed to DNA damaging agents in their natural environment do not undergo continuous cycles of replication but are more frequently engaged in gene transcription. Luciferase gene expression analysis with DNA templates containing uracil or 8-oxoguanine, placed at a defined position, indicated that in nondividing Escherichia coli cells, efficient mutagenic lesion bypass does occur in vivo during...
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