Article
In vivo technique for determining transcriptional mutagenesis.
Methods (San Diego, Calif.) - 1 Oct 2000
You H J, Viswanathan A, Doetsch P W
Abstract excerpt
When an elongating RNA polymerase encounters DNA damage on the template strand of a transcribed gene it can either be arrested by or be transcribed through the lesion. Lesions that arrest RNA polymerases are thought to be subject to transcription-coupled repair, whereas that damage that is bypassed can cause miscoding, resulting in "mutations" in the transcript (transcriptional mutagenesis). We have developed a...
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