Article
Isolation and characterization of RNA polymerase rpoB mutations that alter transcription slippage during elongation in Escherichia coli.
The Journal of biological chemistry - 25 Jan 2013
Zhou Yan Ning, Lubkowska Lucyna, Hui Monica, Court Carolyn, Chen Shuo, Court Donald L, Strathern Jeffrey, Jin Ding Jun, Kashlev Mikhail
Abstract excerpt
Transcription fidelity is critical for maintaining the accurate flow of genetic information. The study of transcription fidelity has been limited because the intrinsic error rate of transcription is obscured by the higher error rate of translation, making identification of phenotypes associated with transcription infidelity challenging. Slippage of elongating RNA polymerase (RNAP) on homopolymeric A/T tracts in...
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