Article
Germ-line epigenetic modification of the murine A vy allele by nutritional supplementation.
Proceedings of the National Academy of Sciences of the United States of America - 14 Nov 2006
Cropley Jennifer E, Suter Catherine M, Beckman Kenneth B, Martin David I K
Abstract excerpt
Environmental effects on phenotype can be mediated by epigenetic modifications. The epigenetic state of the murine A vy allele is highly variable, and determines phenotypic effects that vary in a mosaic spectrum that can be shifted by in utero exposure to methyl donor supplementation. We have asked if methyl donor supplementation affects the germ-line epigenetic state of the A vy allele. We find that the somatic...
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