Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cytosolic phospholipase A(2)-alpha enhances induction of endoplasmic reticulum stress.

Biochimica et biophysica acta - 1 Apr 2010

Ren Guohui, Takano Tomoko, Papillon Joan, Cybulsky Andrey V

Abstract excerpt

Induction of endoplasmic reticulum (ER) stress by the complement membrane attack complex is enhanced by activation of cytosolic phospholipase A(2)-alpha (cPLA(2)). To address mechanisms by which cPLA(2) may modulate ER stress, we produced a mutant cPLA(2), containing an ER targeting domain (cPLA(...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Calnexin
Share to HSP70 Heat-Shock Proteins
Share to Ionomycin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ionophores

Share to Kidney Glomerulus

Share to Phospholipids

Share to Superoxides

Share to Tunicamycin

Source

Identifiers

PMID: 20138193
DOI: 10.1016/j.bbamcr.2010.01.020

Genes

EBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20138193-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cytosolic phospholipase A(2)-alpha enhances induction of endoplasmic reticulum stress.PMID 20138193Read ↗

JNK and ceramide kinase govern the biogenesis of lipid droplets through activation of group IVA phospholipase A2.Semantic proximity Read ↗

Endoplasmic reticulum stress stimulates the expression of cyclooxygenase-2 through activation of NF-kappaB and pp38 mitogen-activated protein kinase.Semantic proximity Read ↗

Activation of caspase-12, an endoplastic reticulum (ER) resident caspase, through tumor necrosis factor receptor-associated factor 2-dependent mechanism in response to the ER stress.Semantic proximity Read ↗

A brefeldin A-like phenotype is induced by the overexpression of a human ERD-2-like protein, ELP-1.Semantic proximity Read ↗

ALG-2 oscillates in subcellular localization, unitemporally with calcium oscillations.Semantic proximity Read ↗

Interfacial kinetic and binding properties of mammalian group IVB phospholipase A2 (cPLA2beta) and comparison with the other cPLA2 isoforms.Semantic proximity Read ↗

Induction of hepatic metallothionein synthesis by endoplasmic reticulum stress in mice.Semantic proximity Read ↗

Mitochondrial Dok-4 recruits Src kinase and regulates NF-kappaB activation in endothelial cells.Semantic proximity Read ↗

Inhibition of the MEK1/ERK pathway reduces arachidonic acid release independently of cPLA2 phosphorylation and translocation.Semantic proximity Read ↗

A cyclooxygenase-2-dependent prostaglandin E2 biosynthetic system in the Golgi apparatus.Semantic proximity Read ↗

Role of phosphorylation and basic residues in the catalytic domain of cytosolic phospholipase A2alpha in regulating interfacial kinetics and binding and cellular function.Semantic proximity Read ↗

Phosphatidylinositol 4,5-bisphosphate anchors cytosolic group IVA phospholipase A2 to perinuclear membranes and decreases its calcium requirement for translocation in live cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.