Article
A brefeldin A-like phenotype is induced by the overexpression of a human ERD-2-like protein, ELP-1.
Cell - 15 May 1992
Hsu V W, Shah N, Klausner R D
Abstract excerpt
Brefeldin A (BFA) is a unique drug affecting the molecular mechanisms that regulate membrane traffic and organelle structure. BFA's ability to alter retrograde traffic from the Golgi to the endoplasmic reticulum (ER) led us to ask whether the ERD-2 retrieval receptor, proposed to return escaped ER resident proteins from the Golgi, might either interfere with or mimic the effects of the drug. When either human...
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