Article
JNK and ceramide kinase govern the biogenesis of lipid droplets through activation of group IVA phospholipase A2.
The Journal of biological chemistry - 20 Nov 2009
Gubern Albert, Barceló-Torns Miquel, Barneda David, López José M, Masgrau Roser, Picatoste Fernando, Chalfant Charles E, Balsinde Jesús, Balboa María A, Claro Enrique
Abstract excerpt
The biogenesis of lipid droplets (LD) induced by serum depends on group IVA phospholipase A(2) (cPLA(2)alpha). This work dissects the pathway leading to cPLA(2)alpha activation and LD biogenesis. Both processes were Ca(2+)-independent, as they took place after pharmacological blockade of Ca(2+) transients elicited by serum or chelation with 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid...
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