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Article

A cyclooxygenase-2-dependent prostaglandin E2 biosynthetic system in the Golgi apparatus.

The Journal of biological chemistry - 27 Feb 2015

Yuan Chong, Smith William L

Abstract excerpt

Cyclooxygenases (COXs) catalyze the committed step in prostaglandin (PG) biosynthesis. COX-1 is constitutively expressed and stable, whereas COX-2 is inducible and short lived. COX-2 is degraded via endoplasmic reticulum (ER)-associated degradation (ERAD) following post-translational glycosylation of Asn-594. COX-1 and COX-2 are found in abundance on the luminal surfaces of the ER and inner membrane of the...

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Identifiers

PMID: 25548276
DOI: 10.1074/jbc.M114.632463
PMCID: PMC4342474

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