Article
Endoplasmic reticulum stress stimulates the expression of cyclooxygenase-2 through activation of NF-kappaB and pp38 mitogen-activated protein kinase.
The Journal of biological chemistry - 5 Nov 2004
Hung Jui-Hsiang, Su Ih-Jen, Lei Huan-Yao, Wang Hui-Ching, Lin Wan-Chi, Chang Wen-Tsan, Huang Wenya, Chang Wen-Chang, Chang Yung-Sheng, Chen Ching-Chow, Lai Ming-Derg
Abstract excerpt
Expression of mutant proteins or viral infection may interfere with proper protein folding activity in the endoplasmic reticulum (ER). Several pathways that maintain cellular homeostasis were activated in response to these ER disturbances. Here we investigated which of these ER stress-activated pathways induce COX-2 and potentially oncogenesis. Tunicamycin and brefeldin A, two ER stress inducers, increased the...
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