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Article

Mitochondrial Dok-4 recruits Src kinase and regulates NF-kappaB activation in endothelial cells.

The Journal of biological chemistry - 15 Jul 2005

Itoh Seigo, Lemay Serge, Osawa Masaki, Che Wenyi, Duan Yuntao, Tompkins Andrew, Brookes Paul S, Sheu Shey-Shing, Abe Jun-Ichi

Abstract excerpt

The downstream of kinase (Dok) family of adapter proteins consists of at least five members structurally characterized by an NH2-terminal tandem of conserved pleckstrin homology and phosphotyrosine binding domains linked to a unique COOH-terminal region. To determine the role of the novel adapter protein Dok-4 in endothelial cells, we first investigated the cell localization of Dok-4. Most surprisingly,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15855164
DOI: 10.1074/jbc.M410262200

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mitochondrial Dok-4 recruits Src kinase and regulates NF-kappaB activation in endothelial cells.PMID 15855164Read ↗

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