Article
Influence of lever structure on myosin 5a walking.
Proceedings of the National Academy of Sciences of the United States of America - 9 Feb 2010
Oke Olusola A, Burgess Stan A, Forgacs Eva, Knight Peter J, Sakamoto Takeshi, Sellers James R, White Howard, Trinick John
Abstract excerpt
Using electron microscopy and image processing, we have observed myosin 5a modified with lever arms of different lengths (four, six, and eight calmodulin-binding IQ domains) and orientations walking along actin filaments. Step lengths were dependent on lever length: 8IQ > 6IQ > 4IQ, which is cons...
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