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Article

Kinetic signatures of myosin-5B, the motor involved in microvillus inclusion disease.

The Journal of biological chemistry - 3 Nov 2017

Heissler Sarah M, Chinthalapudi Krishna, Sellers James R

Abstract excerpt

Myosin-5B is a ubiquitous molecular motor that transports cargo vesicles of the endomembrane system in intracellular recycling pathways. Myosin-5B malfunction causes the congenital enteropathy microvillus inclusion disease, underlining its importance in cellular homeostasis. Here we describe the interaction of myosin-5B with F-actin, nucleotides, and the pyrazolopyrimidine compound myoVin-1. We show that...

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Identifiers

PMID: 28882893
DOI: 10.1074/jbc.M117.801456
PMCID: PMC5672057

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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