Article

Conformational changes linked to ADP release from human cardiac myosin bound to actin-tropomyosin

2022-09-23

Abstract excerpt

Following binding to the thin filament, β-cardiac myosin couples ATP-hydrolysis to conformational rearrangements in the myosin motor that drive myofilament sliding and cardiac ventricular contraction. However, key features of the cardiac-specific actin-myosin interaction remain uncertain, including the structural effect of ADP release from myosin, which is ratelimiting during force generation. In fact, ADP release...

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Literature Corpus work: e31b0066-c155-5e65-a272-8e1b380e75ba
DOI: 10.1101/2022.09.23.509077

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