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Article

The motor domain determines the large step of myosin-V.

Nature - 10 Jan 2002

Tanaka Hiroto, Homma Kazuaki, Iwane Atsuko Hikikoshi, Katayama Eisaku, Ikebe Reiko, Saito Junya, Yanagida Toshio, Ikebe Mitsuo

Abstract excerpt

Class-V myosin proceeds along actin filaments with large ( approximately 36 nm) steps. Myosin-V has two heads, each of which consists of a motor domain and a long (23 nm) neck domain. In accordance with the widely accepted lever-arm model, it was suggested that myosin-V steps to successive (36 nm) target zones along the actin helical repeat by tilting its long neck (lever-arm). To test this hypothesis, we...

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Identifiers

PMID: 11805840
DOI: 10.1038/415192a

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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