Article

Conformational State of Myosin’s Disordered Loop 2 Structure Mediates Actomyosin Association During Crossbridge Formation

2025-08-15

Abstract excerpt

The binding of myosin to actin to form crossbridges is a critical step for force generation by sarcomeres. A recent cryo-electron microscopy structure has resolved the weakly-bound actomyosin complex (AM.ADP.Pi); however, the structural and dynamic factors that influence actin-myosin association are unclear. The disordered loop 2 of myosin is thought to mediate actomyosin interactions in complex, chemomechanical s...

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Literature Corpus work: 8b164be1-c2c6-5152-bbc9-9fd773b5588d
DOI: 10.1101/2025.08.13.670102

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