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Article

MEK5/ERK5 signaling modulates endothelial cell migration and focal contact turnover.

The Journal of biological chemistry - 11 Sept 2009

Spiering Désirée, Schmolke Mirco, Ohnesorge Nils, Schmidt Marc, Goebeler Matthias, Wegener Joachim, Wixler Viktor, Ludwig Stephan

Abstract excerpt

The formation of new blood vessels from pre-existing ones requires highly coordinated restructuring of endothelial cells (EC) and the surrounding extracellular matrix. Directed EC migration is a central step in this process and depends on cellular signaling cascades that initiate and control the structural rearrangements. On the basis of earlier findings that ERK5 deficiency in mouse EC results in massive defects...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19605361
DOI: 10.1074/jbc.M109.042911
PMCID: PMC2757201

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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