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Article

CaM kinase II delta2-dependent regulation of vascular smooth muscle cell polarization and migration.

American journal of physiology. Cell physiology - 1 Jun 2008

Mercure Melissa Z, Ginnan Roman, Singer Harold A

Abstract excerpt

Previous studies indicate involvement of the multifunctional Ca2+/calmodulin-dependent protein kinase II (CaMKII) in vascular smooth muscle (VSM) cell migration. In the present study, molecular loss-of-function studies were used specifically to assess the role of the predominant CaMKII delta2 isoform on VSM cell migration using a scratch wound healing assay. Targeted CaMKII delta2 knockdown using siRNA or...

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Identifiers

PMID: 18385282
DOI: 10.1152/ajpcell.90638.2007
PMCID: PMC3689296

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