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Article

CCM2 and PAK4 act downstream of atrial natriuretic peptide signaling to promote cell spreading.

The Biochemical journal - 19 May 2017

Miura Koichi, Nojiri Takashi, Akitake Yoshiharu, Ando Koji, Fukuhara Shigetomo, Zenitani Masahiro, Kimura Toru, Hino Jun, Miyazato Mikiya, Hosoda Hiroshi, Kangawa Kenji

Abstract excerpt

Atrial natriuretic peptide (ANP) is a cardiac hormone released by the atrium in response to stretching forces. Via its receptor, guanylyl cyclase-A (GC-A), ANP maintains cardiovascular homeostasis by exerting diuretic, natriuretic, and hypotensive effects mediated, in part, by endothelial cells. Both in vivo and in vitro, ANP enhances endothelial barrier function by reducing RhoA activity and reorganizing the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 28432261
DOI: 10.1042/BCJ20160841

Genes

CCM2
PAK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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