Article
Sexually dimorphic interaction between the DRD1 and COMT genes in schizophrenia.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jun 2010
Hoenicka Janet, Garrido Elena, Ponce Guillermo, Rodríguez-Jiménez Roberto, Martínez Isabel, Rubio Gabriel, Jiménez-Arriero Miguel Angel, Palomo Tomás
Abstract excerpt
Dopaminergic dysfunction in the prefrontal cortex (PFC) is involved in the pathophysiology of schizophrenia. In the PFC, dopamine signalling largely depends on the D1 receptors, which are coded by the DRD1 gene, and on the regulation of dopamine levels by the enzyme catechol-O-methyltransferase (COMT). Here, we investigate the role of DRD1 and its interaction with the COMT gene in schizophrenic patients. In two...
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