Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The catechol-O-methyl-transferase gene in tardive dyskinesia.

The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry - 1 Sept 2010

Zai Clement C, Tiwari Arun K, Müller Daniel J, De Luca Vincenzo, Shinkai Takahiro, Shaikh Sajid, Ni Xingqun, Sibony David, Voineskos Aristotle N, Meltzer Herbert Y, Lieberman Jeffrey A, Potkin Steven G, Remington Gary, Kennedy James L

Abstract excerpt

UNLABELLED: Tardive dyskinesia (TD) is a severe and potentially irreversible motor side effect linked to long-term antipsychotic exposure. Changes in dopamine neurotransmission have been implicated in the etiology of TD, and catechol-O-methyl-transferase (COMT) is an enzyme that metabolizes dopamine. OBJECTIVES: We investigated five single-nucleotide polymorphisms in addition to the functional Val158Met variant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Analysis of Variance
Share to Antipsychotic Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Catechol O-Methyltransferase

Share to Movement Disorders

Share to Odds Ratio

Share to Polymorphism, Single Nucleotide

Share to Schizophrenia

Share to Sex Distribution

Source

Identifiers

PMID: 20586531
DOI: 10.3109/15622975.2010.486043

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The catechol-O-methyl-transferase gene in tardive dyskinesia.PMID 20586531Read ↗

Associations between Catechol-O-methyltransferase (COMT) polymorphisms and cognitive impairments, psychiatric symptoms and tardive dyskinesia in schizophrenia.Semantic proximity Read ↗

Val158Met polymorphism in the catechol-O-methyltransferase (COMT) gene is not associated with tardive dyskinesia in schizophrenia.Semantic proximity Read ↗

Negative association between catechol-O-methyltransferase (COMT) gene Val158Met polymorphism and persistent tardive dyskinesia in schizophrenia.Semantic proximity Read ↗

Clinical involvement of catechol-O-methyltransferase polymorphisms in schizophrenia spectrum disorders: influence on the severity of psychotic symptoms and on the response to neuroleptic treatment.Semantic proximity Read ↗

Tardive dyskinesia is not associated with the polymorphisms of 5-HT2A receptor gene, serotonin transporter gene and catechol-<i>o</i>-methyltransferase gene <sup>⋆</sup>Semantic proximity Read ↗

Association between COMT gene rs165599 SNP and schizophrenia: A meta-analysis of case-control studies.Semantic proximity Read ↗

Polymorphisms of dopamine degradation enzyme (COMT and MAO) genes and tardive dyskinesia in patients with schizophrenia.Semantic proximity Read ↗

Meta-analysis of association between genetic variants in COMT and schizophrenia: an update.Semantic proximity Read ↗

Association study between the rs165599 catechol-O-methyltransferase genetic polymorphism and schizophrenia in a Brazilian sample.Semantic proximity Read ↗

The Role of a Catechol-O-Methyltransferase (COMT) Val158Met Genetic Polymorphism in Schizophrenia: A Systematic Review and Updated Meta-analysis on 32,816 Subjects.Semantic proximity Read ↗

Association of the 3' region of COMT with schizophrenia in Taiwan.Semantic proximity Read ↗

Genetic susceptibility to tardive dyskinesia among schizophrenia subjects: IV. Role of dopaminergic pathway gene polymorphisms.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.