Gender-specific COMT Val158Met polymorphism association in Spanish schizophrenic patients.

doi:10.1002/ajmg.b.30957

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Article

Gender-specific COMT Val158Met polymorphism association in Spanish schizophrenic patients.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 5 Jan 2010

Hoenicka Janet, Garrido Elena, Martínez Isabel, Ponce Guillermo, Aragüés María, Rodríguez-Jiménez Roberto, España-Serrano Laura, Alvira-Botero Ximena, Santos José Luis, Rubio Gabriel, Jiménez-Arriero Miguel Angel, Palomo Tomás

Abstract excerpt

The functional Val158Met polymorphism (rs4680) located at the gene that codes for the catechol-O-methyltransferase (COMT) has been extensively investigated in schizophrenia although current data are still controversial. Since COMT activity is sexually dimorphic, we carried out two independent studies in homogeneous samples of male and female Spanish schizophrenic patients. In males, we found an association...

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PMID: 19367610
DOI: 10.1002/ajmg.b.30957

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COMT

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