Article
An association study between dopamine D1 receptor gene polymorphisms and the risk of schizophrenia.
Brain research - 28 Oct 2011
Zhu Feng, Yan Chun-xia, Wang Qian, Zhu Yong-sheng, Zhao Yan, Huang Jiong, Zhang Hong-bo, Gao Cheng-ge, Li Sheng-bin
Abstract excerpt
Deficits in dopamine transmission at D1 receptors in the PFC are implicated in schizophrenia. Genetic polymorphisms in functional regions of DRD1 have a plausible role in modulating the risk of schizophrenia. In order to evaluate the role of DRD1 polymorphisms as a risk factor for schizophrenia, we performed a detailed analysis of possible functional single nucleotide polymorphisms (SNPs) in regulatory and coding...
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