Tissue-specific transcription of the rat tyrosine hydroxylase gene requires synergy between an AP-1 motif and an overlapping E box-containing dyad.

doi:10.1016/0896-6273(92)90220-8

Back to search

Article

Tissue-specific transcription of the rat tyrosine hydroxylase gene requires synergy between an AP-1 motif and an overlapping E box-containing dyad.

Neuron - 1 Jul 1992

Yoon S O, Chikaraishi D M

Abstract excerpt

Transcription of tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine biosynthesis, is regulated in a tissue-specific manner. We have identified sequences from -205 to -182 as the minimal enhancer for TH in pheochromocytoma cells using site-directed mutagenesis. This segment (TGAT...

Topics

Adrenal Gland Neoplasms
Animals
Base Sequence
DNA
Gene Expression
Molecular Sequence Data
Mutation
Oligonucleotides
Pheochromocytoma
Rats
Transcription, Genetic
Transfection
Tumor Cells, Cultured
Tyrosine 3-Monooxygenase

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.