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Article

An adverse outcome pathway for immune-mediated and allergic hepatitis: a case study with the NSAID diclofenac.

Archives of toxicology - 1 Aug 2020

Selvaraj Saravanakumar, Oh Jung-Hwa, Borlak Jürgen

Abstract excerpt

Many drugs have the potential to cause drug-induced liver injury (DILI); however, underlying mechanisms are diverse. The concept of adverse outcome pathways (AOPs) has become instrumental for risk assessment of drug class effects. We report AOPs specific for immune-mediated and drug hypersensitivity/allergic hepatitis by considering genomic, histo- and clinical pathology data of mice and dogs treated with...

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Identifiers

PMID: 32372211
DOI: 10.1007/s00204-020-02767-6
PMCID: PMC7395045

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