Article

Potential of in vivo stress reporter models to reduce animal use and provide mechanistic insights in toxicity studies

2023-08-10

Abstract excerpt

Chemical risk assessment ensures protection from the toxic effects of drugs and manmade chemicals. To comply with regulatory guidance, studies in complex organisms are required, as well as mechanistic studies to establish the relevance of any toxicities observed to man. Although in vitro toxicity models are improving, in vivo studies remain central to this process. Such studies are invariably time-consuming and...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 80f60f01-b60c-571c-89a0-4ff15473b5bc
DOI: 10.12688/f1000research.123077.2

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Potential of in vivo stress reporter models to reduce animal use and provide mechanistic insights in toxicity studiesDOI 10.12688/f1000research.123077.2Read

ANIMAL MODELS OF HUMAN DISEASE IN DRUG SAFETY ASSESSMENTSemantic proximity Read

Using Mice to Model Human Disease: Understanding the Roles of Baseline Housing-Induced and Experimentally Imposed Stresses in Animal Welfare and Experimental ReproducibilitySemantic proximity Read

Guidelines on severity assessment and classification of genetically altered mouse and rat lines.Semantic proximity Read

Toxicogenomics and systems toxicology: aims and prospects.Semantic proximity Read

Transgenic animal mutation models: a review of the models and how they function.Semantic proximity Read

Use of genetically heterogeneous rats and mice in toxicological research: a personal perspective.Semantic proximity Read

Transgenic animal models in toxicology: historical perspectives and future outlook.Semantic proximity Read

Welfare phenotyping of genetically-modified mice.Semantic proximity Read

A systems approach reveals species differences in hepatic stress response capacitySemantic proximity Read

Minimizing strain influences in a genetically modified mouse phenotyping platform.Semantic proximity Read

Promising tools into oxidative stress: A review of non-rodent model organismsSemantic proximity Read

Use of Transgenic Mice in Carcinogenicity Hazard AssessmentSemantic proximity Read