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Article

Nitrosative Stress and Lipid Homeostasis as a Mechanism for Zileuton Hepatotoxicity and Resistance in Genetically Sensitive Mice.

Toxicological sciences : an official journal of the Society of Toxicology - 1 Jun 2020

You Dahea, Lyn-Cook Lascelles E, Gatti Daniel M, Bell Natalie, Mayeux Philip R, James Laura P, Mattes William B, Larson Gary J, Harrill Alison H

Abstract excerpt

Zileuton is an orally active inhibitor of leukotriene synthesis for maintenance treatment of asthma, for which clinical usage has been associated with idiosyncratic liver injury. Mechanistic understanding of zileuton toxicity is hampered by the rarity of the cases and lack of an animal model. A promising model for mechanistic study of rare liver injury is the Diversity Outbred (J:DO) mouse population, with...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32170957
DOI: 10.1093/toxsci/kfaa037
PMCID: PMC7253212

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