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Article

Dietary Caffeine Synergizes Adverse Peripheral and Central Responses to Anesthesia in Malignant Hyperthermia Susceptible Mice.

Molecular pharmacology - 1 Oct 2020

Aleman Monica, Zhang Rui, Feng Wei, Qi Lihong, Lopez Jose R, Crowe Chelsea, Dong Yao, Cherednichenko Genady, Pessah Isaac N

Abstract excerpt

Ryanodine receptor (RYR) mutations confer stress-triggered malignant hyperthermia (MH) susceptibility. Dietary caffeine (CAF) is the most commonly consumed psychoactive compound by humans. CAF-triggered Ca2+ release and its influences on skeletal muscle contractility are widely used as experimental tools to study RYR function/dysfunction and diagnose MH susceptibility. We hypothesize that dietary CAF achieving...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32764093
DOI: 10.1124/mol.120.119412
PMCID: PMC7491310

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