Article
CRY Drives Cyclic CK2-Mediated BMAL1 Phosphorylation to Control the Mammalian Circadian Clock.
PLoS biology - 1 Jan 2015
Tamaru Teruya, Hattori Mitsuru, Honda Kousuke, Nakahata Yasukazu, Sassone-Corsi Paolo, van der Horst Gijsbertus T J, Ozawa Takeaki, Takamatsu Ken
Abstract excerpt
Intracellular circadian clocks, composed of clock genes that act in transcription-translation feedback loops, drive global rhythmic expression of the mammalian transcriptome and allow an organism to anticipate to the momentum of the day. Using a novel clock-perturbing peptide, we established a pivotal role for casein kinase (CK)-2-mediated circadian BMAL1-Ser90 phosphorylation (BMAL1-P) in regulating central and...
Topics
- ARNTL Transcription Factors
- Animals
- Casein Kinase II
- Cell Line
- Cells, Cultured
- Circadian Clocks
- Cryptochromes
- Embryo, Mammalian
- Humans
- Mice
- Mice, Knockout
- Mice, Transgenic
- Mutation
- Phosphorylation