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Emerging roles of DYRK2 in cancer

29 Dec 2020

Abstract excerpt

Over the last decade, the CMGC kinase DYRK2 has been reported as a tumor suppressor across various cancers triggering major antitumor and proapoptotic signals in breast, colon, liver, ovary, brain, and lung cancers, with lower DYRK2 expression correlated with poorer prognosis in patients. Contrary to this, various medicinal chemistry studies reported robust antiproliferative properties of DYRK2 inhibitors,...

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PMID: 33376136
DOI: 10.1074/jbc.rev120.015217

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