Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multiple functions of DYRK2 in cancer and tissue development

10 Sept 2019

Abstract excerpt

Dual-specificity tyrosine-regulated kinases (DYRKs) are evolutionarily conserved from yeast to mammals. Accumulating studies have revealed that DYRKs have important roles in regulation of the cell cycle and survival. DYRK2, a member of the class II DYRK family protein, is a key regulator of p53, and phosphorylates it at Ser46 to induce apoptosis in response to DNA damage. Moreover, recent studies have uncovered...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Down syndrome and intellectual disability research
Share to Neuroblastoma Research and Treatments
Share to Occupational and environmental lung diseases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 31505048
DOI: 10.1002/1873-3468.13601

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multiple functions of DYRK2 in cancer and tissue developmentPMID 31505048Read ↗

New insights into the roles for DYRK family in mammalian development and congenital diseasesSemantic proximity Read ↗

The DYRK Family of Kinases in Cancer: Molecular Functions and Therapeutic OpportunitiesSemantic proximity Read ↗

DYRK1A: the double-edged kinase as a protagonist in cell growth and tumorigenesisSemantic proximity Read ↗

Engagement of DYRK2 in proper control for cell division.Semantic proximity Read ↗

Emerging role of DYRK family protein kinases as regulators of protein stability in cell cycle controlSemantic proximity Read ↗

DYRK family of protein kinases: evolutionary relationships, biochemical properties, and functional rolesSemantic proximity Read ↗

DYRK1A: a down syndrome-related dual protein kinase with a versatile role in tumorigenesisSemantic proximity Read ↗

Emerging roles of DYRK2 in cancerSemantic proximity Read ↗

Defining novel targets and functions of the protein kinase DYRK2Semantic proximity Read ↗

DYRK1A is required for maintenance of cancer stemness, contributing to tumorigenic potential in oral/oropharyngeal squamous cell carcinomaSemantic proximity Read ↗

Functions of SRPK , CLK and DYRK kinases in stem cells, development, and human developmental disordersSemantic proximity Read ↗

THE FAM53C/DYRK1A axis regulates the G1/S transition of the cell cycleSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.