DYRK family of protein kinases: evolutionary relationships, biochemical properties, and functional roles

doi:10.1096/fj.10-165837

Article

DYRK family of protein kinases: evolutionary relationships, biochemical properties, and functional roles

3 Nov 2010

Abstract excerpt

ABSTRACT Dual‐specificity tyrosine‐regulated kinases (DYRKs) comprise a family of protein kinases within the CMGC group of the eukaryotic kinome. Members of the DYRK family are found in 4 (animalia, plantae, fungi, and protista) of the 5 main taxa or kingdoms, and all DYRK proteins studied to date share common structural, biochemical, and functional properties with their ancestors in yeast. Recent work on DYRK...

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