Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Phosphorylation and inactivation of glycogen synthase kinase 3β (GSK3β) by dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A).

The Journal of biological chemistry - 23 Jan 2015

Song Woo-Joo, Song Eun-Ah Christine, Jung Min-Su, Choi Sun-Hee, Baik Hyung-Hwan, Jin Byung Kwan, Kim Jeong Hee, Chung Sul-Hee

Abstract excerpt

Glycogen synthase kinase 3β (GSK3β) participates in many cellular processes, and its dysregulation has been implicated in a wide range of diseases such as obesity, type 2 diabetes, cancer, and Alzheimer disease. Inactivation of GSK3β by phosphorylation at specific residues is a primary mechanism by which this constitutively active kinase is controlled. However, the regulatory mechanism of GSK3β is not fully...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 3T3-L1 Cells
Share to Adipose Tissue

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Dyrk Kinases

Share to Glycogen Synthase Kinase 3

Share to Glycogen Synthase Kinase 3 beta

Share to Protein-Tyrosine Kinases

Share to RNA, Small Interfering

Share to Threonine

Source

Open in PubMed Open full text

Identifiers

PMID: 25477508
DOI: 10.1074/jbc.M114.594952
PMCID: PMC4303684

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phosphorylation and inactivation of glycogen synthase kinase 3β (GSK3β) by dual-specificity tyrosine phosphorylation-regulated kinase 1A (Dyrk1A).PMID 25477508Read ↗

DYRK1A and glycogen synthase kinase 3beta, a dual-kinase mechanism directing proteasomal degradation of CRY2 for circadian timekeeping.Semantic proximity Read ↗

TIGAR exacerbates obesity by triggering LRRK2-mediated defects in macroautophagy and chaperone-mediated autophagy in adipocytesSemantic proximity Read ↗

Phosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinases.Semantic proximity Read ↗

Tissue-specific role of glycogen synthase kinase 3beta in glucose homeostasis and insulin action.Semantic proximity Read ↗

Development of glucose intolerance in male transgenic mice overexpressing human glycogen synthase kinase-3beta on a muscle-specific promoter.Semantic proximity Read ↗

Glycogen synthase kinase 3beta is tyrosine phosphorylated by PYK2.Semantic proximity Read ↗

A form of the metabolic syndrome associated with mutations in DYRK1B.Semantic proximity Read ↗

Analysis of DYRK1B, PPARG, and CEBPB Expression Patterns in Adipose-Derived Stem Cells from Patients carrying DYRK1B R102C and Healthy Individuals During AdipogenesisSemantic proximity Read ↗

Effects of mutations in Wnt/β-catenin, hedgehog, Notch and PI3K pathways on GSK-3 activity-Diverse effects on cell growth, metabolism and cancer.Semantic proximity Read ↗

Glycogen synthase kinase-3 in insulin and Wnt signalling: a double-edged sword?Semantic proximity Read ↗

Deletion of Cardiomyocyte Glycogen Synthase Kinase-3 Beta (GSK-3β) Improves Systemic Glucose Tolerance with Maintained Heart Function in Established Obesity.Semantic proximity Read ↗

Lipid kinase PIK3C3 maintains healthy brown and white adipose tissues to prevent metabolic diseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.