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Bypass of Senescence After Disruption of p21 <sup> <i>CIP1/WAF1</i> </sup> Gene in Normal Diploid Human Fibroblasts

8 Aug 1997

Abstract excerpt

Most somatic cells die after a finite number of cell divisions, a phenomenon described as senescence. The p21(CIP1/WAF1) gene encodes an inhibitor of cyclin-dependent kinases. Inactivation of p21 by two sequential rounds of targeted homologous recombination was sufficient to bypass senescence in normal diploid human fibroblasts. At the checkpoint between the prereplicative phase of growth and the phase of...

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PMID: 9242615
DOI: 10.1126/science.277.5327.831

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