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Article

How to become immortal: let MEFs count the ways

18 Mar 2010

Abstract excerpt

Understanding the molecular mechanisms and biological consequences of genetic changes occurring during bypass of cellular senescence spans a broad area of medical research from the cancer field to regenerative medicine. Senescence escape and immortalisation have been intensively studied in murine embryonic fibroblasts as a model system, and are known to occur when the p53/ARF tumour suppressor pathway is...

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PMID: 20378935
DOI: 10.18632/aging.100129

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