Article

Induced Pluripotent Stem Cell-Derived Fibroblasts Efficiently Engage Senescence Pathways But Show Increased Sensitivity to Stress Inducers

2024-04-26

Abstract excerpt

The risk of malignant transformation of induced pluripotent stem cells (iPSC)-derived cells in response to DNA damage is a potential concern as the tumor suppressor genes TP53 and CDKN2A are transiently inactivated during reprogramming. Here, we evaluated the integrity of cellular senescence pathways and DNA double-strand break (DSB) repair in iPSC-derived human fibroblasts (i-HF) compared to their parental skin f...

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Literature Corpus work: 37703141-d835-50e5-bb6b-22d2bad67a82
DOI: 10.20944/preprints202404.1775.v1

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