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Article

Role of p14ARF in Replicative and Induced Senescence of Human Fibroblasts

1 Oct 2001

Abstract excerpt

Following a proliferative phase of variable duration, most normal somatic cells enter a growth arrest state known as replicative senescence. In addition to telomere shortening, a variety of environmental insults and signaling imbalances can elicit phenotypes closely resembling senescence. We used p53(-/-) and p21(-/-) human fibroblast cell strains constructed by gene targeting to investigate the involvement of...

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PMID: 11564860
DOI: 10.1128/mcb.21.20.6748-6757.2001

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