Article
Gain-of-Function p53N236S Mutation Drives the Bypassing of HRasV12-Induced Cellular Senescence via PGC-1α.
International journal of molecular sciences - 14 Feb 2023
Yang Hao, Zhang Ke, Guo Yusheng, Guo Xin, Hou Kailong, Hou Jing, Luo Ying, Liu Jing, Jia Shuting
Abstract excerpt
One of the key steps in tumorigenic transformation is immortalization in which cells bypass cancer-initiating barriers such as senescence. Senescence can be triggered by either telomere erosion or oncogenic stress (oncogene-induced senescence, OIS) and undergo p53- or Rb-dependent cell cycle arrest. The tumor suppressor p53 is mutated in 50% of human cancers. In this study, we generated p53N236S (p53S) mutant...
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