Article
Alterations in p53 and p16INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts.
Molecular and cellular biology - 1 Sept 1995
Rogan E M, Bryan T M, Hukku B, Maclean K, Chang A C, Moy E L, Englezou A, Warneford S G, Dalla-Pozza L, Reddel R R
Abstract excerpt
Normal cells have a strictly limited growth potential and senesce after a defined number of population doublings (PDs). In contrast, tumor cells often exhibit an apparently unlimited proliferative potential and are termed immortalized. Although spontaneous immortalization of normal human cells in vitro is an extremely rare event, we observed this in fibroblasts from an affected member of a Li-Fraumeni syndrome...
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