Article
Alterations in p53 and p16INK4 expression and telomere length during spontaneous immortalization of Li-Fraumeni syndrome fibroblasts.
Molecular and cellular biology - 1 Sept 1995
Rogan E M, Bryan T M, Hukku B, Maclean K, Chang A C, Moy E L, Englezou A, Warneford S G, Dalla-Pozza L, Reddel R R
Abstract excerpt
Normal cells have a strictly limited growth potential and senesce after a defined number of population doublings (PDs). In contrast, tumor cells often exhibit an apparently unlimited proliferative potential and are termed immortalized. Although spontaneous immortalization of normal human cells in...
Topics
- Animals
- Base Sequence
- Carcinogenicity Tests
- Carrier Proteins
- Cell Transformation, Neoplastic
- Cells, Cultured
- Cellular Senescence
- Chromosome Aberrations
- Cyclin-Dependent Kinase Inhibitor p16
- DNA Nucleotidylexotransferase
- Fibroblasts
- Heterozygote
- Karyotyping