Article
RASless MEFs as a Tool to Study RAS-Dependent and RAS-Independent Functions.
Methods in molecular biology (Clifton, N.J.) - 1 Jan 2021
Lechuga Carmen G, Salmón Marina, Paniagua Guillem, Guerra Carmen, Barbacid Mariano, Drosten Matthias
Abstract excerpt
RAS proteins are key players in multiple cellular processes. To study the role of RAS proteins individually or in combination, we have developed MEFs that can be rendered RASless, i.e., devoid of all endogenous RAS isoforms. These cells have significantly contributed to our understanding of the requirements for RAS functions in cell proliferation as well as their implications in diverse cellular processes. Here,...
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